(19)

(11)

EP 0 598 839 A1

(12)

(43) Date of publication: 01.06.1994 Bulletin 1994/22 (21) Application number: 92918552.0 (22) Date of filing: 17.08.1992

(51) International Patent Classification (IPC):  C07K 14/ 46( . ) C12N 1/ 21( . ) A61K 38/ 00( . ) C07K 14/ 47( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1992/006748 (87) International publication number: WO 1993/004166 (04.03.1993 Gazette 1993/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 16.08.1991 US 19910746032 (71) Applicant: CARNEGIE INSTITUTION OF WASHINGTON Washington, D.C. 20005 (US)	(72) Inventors: MCKNIGHT, Steven, L. Baltimore, MD 21212 (US) THOMPSON, Catherine, C. Baltimore, MD 21211 (US) LAMARCO, Karen, L. Washington, DC 20036 (US) (74) Representative: Smart, Peter John  W.H. BECK, GREENER & CO 7 Stone Buildings Lincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)