(19)

(11)

EP 0 599 859 A1

(12)

(43) Date of publication: 08.06.1994 Bulletin 1994/23 (21) Application number: 92914609.0 (22) Date of filing: 25.06.1992

(51) International Patent Classification (IPC):  C11D 3/ 386( . ) C12N 9/ 24( . ) C12N 15/ 81( . ) C12N 9/ 20( . ) C12N 15/ 55( . ) C12R 1/ 69( . ) (86) International application number: PCT/DK1992/000200 (87) International publication number: WO 1993/000426 (07.01.1993 Gazette 1993/02)

(84) Designated Contracting States: AT BE DE DK ES FR GB IT NL (30) Priority: 25.06.1991 EP 19910610056 (71) Applicants: NOVO NORDISK A/S DK-2880 Bagsvaerd (DK) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) F-75700 Paris Cedex 07 (FR)	(72) Inventors: HJORTH, Siv, Annegrethe DK-2800 Lyngby (DK) WOLDIKE, Helle, Fabricius DK-3540 Lynge (DK) THIM, Lars DK-2820 Gentofte (DK) GORMSEN, Erik DK-2830 Virum (DK) VERGER, Robert F-13009 Marseille (FR) (74) Representative: Jensen, Bo Hammer, et al  c/o Novo Nordisk A/S Novo Allé DK-2880 Bagsvaerd DK-2880 Bagsvaerd (DK)