(19)

(11)

EP 0 599 987 A1

(12)

(43) Date of publication: 08.06.1994 Bulletin 1994/23 (21) Application number: 92918495.0 (22) Date of filing: 14.08.1992

(51) International Patent Classification (IPC):  C07H 19/ 052( . ) A61K 31/ 505( . ) A61K 31/ 70( . ) A61K 31/ 7052( . ) A61K 31/ 7064( . ) C07H 19/ 14( . ) A61K 31/ 415( . ) A61K 31/ 52( . ) A61K 31/ 7042( . ) A61K 31/ 7056( . ) A61P 3/ 06( . ) (86) International application number: PCT/US1992/006828 (87) International publication number: WO 1993/003734 (04.03.1993 Gazette 1993/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 23.08.1991 US 19910748944 12.08.1992 US 19920929752 (71) Applicant: GENSIA, INC. San Diego, CA 92121 (US)	(72) Inventors: VAN DEN BERGHE, Georges, H. B-1970 Wezembeek-Oppem (BE) GRUBER, Harry, E. San Diego, CA 92130 (US) (74) Representative: Sexton, Jane Helen, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)