(19)

(11)

EP 0 600 009 A1

(12)

(43) Date of publication: 08.06.1994 Bulletin 1994/23 (21) Application number: 92918853.0 (22) Date of filing: 21.08.1992

(51) International Patent Classification (IPC):  C07K 14/ 00( . ) C07K 14/ 10( . ) C07K 19/ 00( . ) C12N 15/ 09( . ) G01N 33/ 576( . ) C07K 14/ 02( . ) C07K 14/ 18( . ) C12N 9/ 12( . ) G01N 33/ 53( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1992/007188 (87) International publication number: WO 1993/004088 (04.03.1993 Gazette 1993/06)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI NL (30) Priority: 21.08.1991 US 19910748561 (71) Applicant: ABBOTT LABORATORIES Abbott Park, IL 60064-2204 (US)	(72) Inventors: DAILEY, Stephen, H. Vernon Hills, IL 60061 (US) DESAI, Suresh, M. Libertyville, IL 60048 (US) DEVARE, Sushil, G. Northbrook, IL 60062 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 D-80469 München D-80469 München (DE)