(19)

(11)

EP 0 600 875 A1

(12)

(43) Date of publication: 15.06.1994 Bulletin 1994/24 (21) Application number: 91915262.0 (22) Date of filing: 26.06.1991

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) C07K 14/ 775( . ) C12N 1/ 38( . ) A61K 51/ 12( . ) C12N 1/ 06( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1991/004553 (87) International publication number: WO 1993/000443 (07.01.1993 Gazette 1993/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (71) Applicant: BIO-TECHNOLOGY GENERAL CORPORATION New York NY 10001 (US)	(72) Inventors: LIFSHITZ, Ruth 76 100 Rehovot (IL) FISCHER, Meir 76 100 Rehovot (IL) GREENMAN, Benjamin 76 100 Rehovot (IL) BARTFELD, Daniel North York, Ontario M2N 1X1 (CA) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)