(19)

(11)

EP 0 600 955 A1

(12)

(43) Date of publication: 15.06.1994 Bulletin 1994/24 (21) Application number: 92917490.0 (22) Date of filing: 18.08.1992

(51) International Patent Classification (IPC):  A61K 31/ 38( . ) A61K 31/ 397( . ) A61K 31/ 403( . ) A61K 31/ 415( . ) A61K 31/ 445( . ) A61K 31/ 55( . ) A61P 9/ 00( . ) A61P 43/ 00( . ) C07D 207/ 08( . ) C07D 211/ 22( . ) C07D 211/ 40( . ) C07D 223/ 04( . ) C07D 333/ 68( . ) A61K 31/ 395( . ) A61K 31/ 40( . ) A61K 31/ 404( . ) A61K 31/ 4427( . ) A61K 31/ 47( . ) A61P 1/ 00( . ) A61P 25/ 00( . ) C07D 205/ 04( . ) C07D 209/ 42( . ) C07D 211/ 26( . ) C07D 211/ 56( . ) C07D 295/ 08( . ) C07D 401/ 06( . ) (86) International application number: PCT/GB1992/001519 (87) International publication number: WO 1993/003725 (04.03.1993 Gazette 1993/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 20.08.1991 GB 19910179432 14.09.1991 GB 19910196923 23.01.1992 GB 19920014141 25.02.1992 GB 19920039775 15.04.1992 GB 19920083211 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)

(72) Inventors: KING, Francis, David SmithKline Beecham The Pinnacles Harlow Essex CM19 5AD (GB) GASTER, Laramie, Mary SmithKline Beecham The Pinnacles Harlow Essex CM19 5AD (GB) JOINER, Graham, Francis SmithKline Beecham The Pinnacles Harlow Essex CM19 5AD (GB) RAHMAN, Shirley, Katherine SmithKline Beecham The Pinnacles Harlow Essex CM19 5AD (GB) SANGER, Gareth, John SmithKline Beecham The Pinnacles Harlow Essex CM19 5AD (GB) WARDLE, Kay, Alison SmithKline Beecham The Pinnacles Harlow Essex CM19 5AD (GB) BAXTER, Gordon, Smith SmithKline Beecham The Pinnacles Harlow Essex CM19 5AD (GB) KENNETT, Guy, Anthony SmithKline Beecham The Pinnacles Harlow Essex CM19 5AD (GB) YOUNG, Rodney, Christopher SmithKline Beecham Welwyn Hertfordshire AL6 9AR (GB) VIMAL, Mythily SmithKline Beecham Pharmaceuticals Welwyn Hertfordshire AL6 9AR (GB) KAUMANN, Alberto, Julio SmithKline Beecham Welwyn Hertfordshire AL6 9AR (GB) (74) Representative: Tocher, Pauline, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)