(19)

(11)

EP 0 600 974 A1

(12)

(43) Date of publication: 15.06.1994 Bulletin 1994/24 (21) Application number: 92917699.0 (22) Date of filing: 13.08.1992

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 1/ 16( . ) A61P 17/ 00( . ) A61P 29/ 00( . ) C07K 9/ 00( . ) A61K 38/ 14( . ) A61P 3/ 00( . ) A61P 25/ 30( . ) A61P 37/ 00( . ) (86) International application number: PCT/EP1992/001859 (87) International publication number: WO 1993/003746 (04.03.1993 Gazette 1993/06)

(84) Designated Contracting States: AT BE CH DE DK FR GB IE IT LI LU NL SE (30) Priority: 15.08.1991 YU 19910001412 (71) Applicants: PLIVA Handels GmbH D-22083 Hamburg (DE) PLIVA Farmaceutska, kemijska, prehrambena i kozmeticka industrija, s p.o. 41001 Zagreb (YU)	(72) Inventors: RADOSEVI-STASIC, Biserka 51000 Rijeka (HR) SUSKOVIC, Bozidar 41000 Zagreb (HR) NAUMSKI, Radmila 41000 Zagreb (HR) RUKAVINA, Danijel 51000 Rijeka (HR) (74) Representative: von Füner, Alexander, Dr., et al  Patentanwälte v. Füner, Ebbinghaus, Finck, Postfach 95 01 60 D-81517 München D-81517 München (DE)