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(11)

EP 0 602 098 A1

(12)

(43) Date of publication: 22.06.1994 Bulletin 1994/25 (21) Application number: 92918332.0 (22) Date of filing: 28.08.1992

(51) International Patent Classification (IPC):  A01H 1/ 00( . ) A01N 63/ 00( . ) C07K 14/ 415( . ) C12N 5/ 10( . ) C12N 15/ 29( . ) C12P 21/ 02( . ) A01H 5/ 00( . ) A01N 65/ 00( . ) C07K 14/ 81( . ) C12N 15/ 09( . ) C12N 15/ 82( . ) (86) International application number: PCT/GB1992/001574 (87) International publication number: WO 1993/004586 (18.03.1993 Gazette 1993/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 02.09.1991 GB 19910018730 (71) Applicant: ZENECA LIMITED London W1Y 6LN (GB)

(72) Inventors: BROEKAERT, Willem, Frans B-1700 Dilbeek (BE) CAMMUE, Bruno, Philippe, Angelo B-1652 Alsemberg (BE) OSBORN, Rupert, William Twickenham Middlesex TW2 6SW (GB) REES, Sarah, Bronwen Bracknell Berkshire RG12 3XX (GB) TERRAS, Franky, Raymond, Gerard B-8570 Anzegem (BE) VANDERLEYDEN, Jozef B-3001 Heverlee (BE) (74) Representative: Huskisson, Frank Mackie, et al  ICI Group Patents Services Dept. PO Box 6 Shire Park Bessemer Road Welwyn Garden City Herts, AL7 1HD Welwyn Garden City Herts, AL7 1HD (GB)