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(11)

EP 0 602 125 A1

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(43) Date of publication: 22.06.1994 Bulletin 1994/25 (21) Application number: 92918711.0 (22) Date of filing: 02.09.1992

(51) International Patent Classification (IPC):  A61K 31/ 505( . ) C07D 401/ 06( . ) A61P 43/ 00( . ) C07D 401/ 14( . ) (86) International application number: PCT/JP1992/001117 (87) International publication number: WO 1993/005035 (18.03.1993 Gazette 1993/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL SE (30) Priority: 06.09.1991 US 19910755747 (71) Applicant: FUJISAWA PHARMACEUTICAL CO., LTD. Osaka-shi Osaka 541 (JP)

(72) Inventors: SHIMAZAKI, Norihiko Tsukuba-shi, Ibaraki 305 (JP) ITOH, Yoshikuni Tsukuba-shi, Ibaaki 305 (JP) YATABE, Takumi Tsukuba-shi, Ibaraki 305 (JP) YAMAZAKI, Hitoshi Tsukubashi, Ibaraki 300-26 (JP) HASHIMOTO, Masashi Toride-shi, Ibaraki 302 (JP) TANAKA, Hirokazu Tsuchiura-shi, Ibaraki 300 (JP) (74) Representative: Türk, Dietmar, Dr. rer. nat., et al  Türk, Gille, Hrabal, Leifert Patentanwälte Brucknerstrasse 20 D-40593 Düsseldorf D-40593 Düsseldorf (DE)