(19)
(11) EP 0 602 178 A1

(12)

(43) Date of publication:
22.06.1994 Bulletin 1994/25

(21) Application number: 92919946.0

(22) Date of filing: 27.08.1992
(51) International Patent Classification (IPC): 
G01N 33/ 53( . )
A61K 39/ 395( . )
C07K 14/ 705( . )
C07K 16/ 00( . )
C12N 15/ 02( . )
G01N 33/ 564( . )
A61K 39/ 00( . )
A61P 29/ 00( . )
C07K 14/ 725( . )
C07K 16/ 28( . )
C12P 21/ 08( . )
A61K 38/ 00( . )
(86) International application number:
PCT/US1992/007289
(87) International publication number:
WO 1993/004695 (18.03.1993 Gazette 1993/08)
(84) Designated Contracting States:
AT CH DE FR GB IT LI

(30) Priority: 28.08.1991 US 19910750913
06.01.1992 US 19920817912

(71) Applicants:
  • THE WISTAR INSTITUTE
    Philadelphia Pennsylvania 19104 (US)
  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Philadelphia, Pennsylvania 19104-3147 (US)

(72) Inventors:
  • WILLIAMS, William, V.
    Havertown, PA 19083 (US)
  • WEINER, David, B.
    Merion, PA 19066 (US)

(74) Representative: Stebbing, Peter John Hunter, et al 
Ablett & Stebbing 45 Lancaster Mews Lancaster Gate
London W2 3QQ
London W2 3QQ (GB)

   


(54) T CELL RECEPTOR-BASED THERAPY FOR RHEUMATOID ARTHRITIS