(19)

(11)

EP 0 602 181 A1

(12)

(43) Date of publication: 22.06.1994 Bulletin 1994/25 (21) Application number: 92920106.0 (22) Date of filing: 28.08.1992

(51) International Patent Classification (IPC):  A61K 9/ 00( . ) A61K 9/ 12( . ) (86) International application number: PCT/US1992/007379 (87) International publication number: WO 1993/004671 (18.03.1993 Gazette 1993/08)

(84) Designated Contracting States: DE FR GB IT SE (30) Priority: 03.09.1991 GB 19910018830 (71) Applicant: MINNESOTA MINING AND MANUFACTURING COMPANY St. Paul, Minnesota 55133-3427 (US)	(72) Inventors: OLIVER, Martin J. 51 Pinfold Gate Leicestershire LE11 1BG (GB) JINKS, Philip A. 91 Rockhill Drive Leicestershire LE12 7DS (GB) (74) Representative: Bowman, Paul Alan  LLOYD WISE, TREGEAR & CO. Norman House 105-109 Strand London WC2R OAE London WC2R OAE (GB)