(19)

(11)

EP 0 603 336 A1

(12)

(43) Date of publication: 29.06.1994 Bulletin 1994/26 (21) Application number: 92920871.0 (22) Date of filing: 11.09.1992

(51) International Patent Classification (IPC):  A01N 43/ 40( . ) (86) International application number: PCT/US1992/007709 (87) International publication number: WO 1993/004581 (18.03.1993 Gazette 1993/08)

(84) Designated Contracting States: AT BE DE DK FR GB IE IT LU MC NL SE (30) Priority: 12.09.1991 US 19910758038 (71) Applicant: ZENECA LIMITED London W1Y 6LN (GB)	(72) Inventors: COLBY, S., Robert Benicia, CA 94510 (US) CASEY, John, Stephen Omaha, NB 68818 (US) ANDERSON, James Al Jubeiha, Amman GU30 7LU (JO) (74) Representative: Greaves, Carol Pauline  ICI Group Patents Services Dept. PO Box 6 Shire Park Bessemer Road Welwyn Garden City Herts, AL7 1HD Welwyn Garden City Herts, AL7 1HD (GB)