(19)

(11)

EP 0 604 504 A1

(12)

(43) Date of publication: 06.07.1994 Bulletin 1994/27 (21) Application number: 92919517.0 (22) Date of filing: 26.08.1992

(51) International Patent Classification (IPC):  A61N 1/ 30( . ) A61N 1/ 32( . ) (86) International application number: PCT/US1992/007221 (87) International publication number: WO 1993/003790 (04.03.1993 Gazette 1993/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 26.08.1991 US 19910749928 (71) Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY New Brunswick, NJ 08903 (US)	(72) Inventors: CHIEN, Yie, W. North Brunswick, NJ 08902 (US) SHI, Wei-Min Piscataway, NJ 08854 (US) (74) Representative: Calamita, Roberto, et al  Frank B. Dehn & Co. Imperial House 15-19 Kingsway London WC2B 6UZ London WC2B 6UZ (GB)