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(11)

EP 0 604 529 A1

(12)

(43) Date of publication: 06.07.1994 Bulletin 1994/27 (21) Application number: 92920043.0 (22) Date of filing: 01.09.1992

(51) International Patent Classification (IPC):  A61K 31/ 44( . ) A61P 17/ 00( . ) A61P 43/ 00( . ) C07D 213/ 28( . ) C07D 213/ 54( . ) C07D 401/ 12( . ) A61K 31/ 4418( . ) A61P 37/ 08( . ) C07D 213/ 24( . ) C07D 213/ 30( . ) C07D 213/ 65( . ) (86) International application number: PCT/US1992/007466 (87) International publication number: WO 1993/006085 (01.04.1993 Gazette 1993/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 19.09.1991 US 19910762710 12.11.1991 US 19910790931 18.12.1991 US 19910809593 20.08.1992 US 19920932869 (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia Pennsylvania 19101 (US)

(72) Inventors: CHAMBERS, Pamela, Anne King of Prussia, PA 19406 (US) DAINES, Robert, A. Lansdale, PA 19446 (US) JAKAS, Dalia, R. Norristown, PA 19403 (US) KINGSBURY, William, D. Wayne, PA 19087 (US) PENDRAK, Israil Norristown, PA 19403 (US) (74) Representative: Giddings, Peter John, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)