(19)

(11)

EP 0 604 537 A1

(12)

(43) Date of publication: 06.07.1994 Bulletin 1994/27 (21) Application number: 92920149.0 (22) Date of filing: 14.09.1992

(51) International Patent Classification (IPC):  A61K 6/ 00( . ) A61L 24/ 06( . ) A61L 24/ 10( . ) C08F 291/ 00( . ) C09J 151/ 06( . ) A61L 24/ 04( . ) A61L 24/ 08( . ) C08F 271/ 02( . ) C09J 151/ 00( . ) C09J 191/ 00( . ) (86) International application number: PCT/US1992/007734 (87) International publication number: WO 1993/006144 (01.04.1993 Gazette 1993/09)

(84) Designated Contracting States: DE ES FR GB IT NL (30) Priority: 19.09.1991 US 19910762712 (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia Pennsylvania 19101 (US)	(72) Inventor: GANGADHARAN, Balgopal Caldwell, NJ 07006 (US) (74) Representative: White, Susan Mary  SmithKline Beecham plc Corporate Intellectual Property SB House L/5 Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)