(19)

(11)

EP 0 605 437 A1

(12)

(43) Date of publication: 13.07.1994 Bulletin 1994/28 (21) Application number: 92916147.0 (22) Date of filing: 29.07.1992

(51) International Patent Classification (IPC):  C12N 15/ 113( . ) (86) International application number: PCT/EP1992/001745 (87) International publication number: WO 1993/003053 (18.02.1993 Gazette 1993/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 30.07.1991 IT 1991MI02117 (71) Applicants: UNIVERSITA' DEGLI STUDI DI MILANO I-20122 Milan (IT) PRODOTTI ROCHE S.P.A. I-20131 Milan (IT)	(72) Inventors: MAGGI, Adriana I-20123 Milan (IT) NICOLIN, Angelo I-20121 Milan (IT) (74) Representative: Appoloni, Romano, et al  Ing. Barzanò & Zanardo S.p.A. Via Borgonuovo 10 I-20121 Milano I-20121 Milano (IT)