(19)

(11)

EP 0 605 606 A1

(12)

(43) Date of publication: 13.07.1994 Bulletin 1994/28 (21) Application number: 92920872.0 (22) Date of filing: 23.09.1992

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 37/ 06( . ) C07K 14/ 725( . ) C07K 16/ 28( . ) A61K 39/ 395( . ) C07K 14/ 00( . ) C07K 16/ 00( . ) C07K 19/ 00( . ) (86) International application number: PCT/US1992/008094 (87) International publication number: WO 1993/006135 (01.04.1993 Gazette 1993/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 23.09.1991 US 19910765222 18.10.1991 US 19910779444 18.03.1992 US 19920853366 (71) Applicant: GENENTECH, INC. South San Francisco CA 94080 (US)	(72) Inventor: AMENTO, Edward, P. Portola Valley, CA 94025 (US) (74) Representative: Barz, Peter, Dr.  Schmied-Kowarzik & Partner Siegfriedstrasse 8 D-80803 München D-80803 München (DE)