(19)

(11)

EP 0 607 201 A1

(12)

(43) Date of publication: 27.07.1994 Bulletin 1994/30 (21) Application number: 92920534.0 (22) Date of filing: 03.10.1992

(51) International Patent Classification (IPC):  A61K 31/ 40( . ) (86) International application number: PCT/EP1992/002295 (87) International publication number: WO 1993/006826 (15.04.1993 Gazette 1993/10)

(84) Designated Contracting States: IT (30) Priority: 08.10.1991 GB 19910021289 (71) Applicant: SMITHKLINE BEECHAM FARMACEUTICI S.p.A. I-20021 Baranzate di Bollate (MI) (IT)	(72) Inventors: CHIODINI, Laura Smithkline Beecham Farmaceutici I-1-Trezzano (IT) PEPEU, Giancarlo Florence University I-65-50135 Firenze (IT) (74) Representative: Rutter, Keith, Dr.  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)