(57) Disclosed are x-ray contrast compositions for oral or retrograde examination of the
gastrointestinal tract comprising a polymeric material capable of forming a coating
on the gastrointestinal tract and an x-ray producing
agent of the formula
or a pharmaceutically acceptable salt thereof,
and methods for their use in diagnostic radiology of the gastrointestinal tract wherein
Z = H, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can
be substituted with halogen or halo-lower-alkyl groups;
R = C1-C25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl,
aryl, lower-alkoxy, hydroxy, carboxy lower-alkoxycarbonyl or lower-alkoxy-carbonyloxy,
(CR1R2)p-CR3 =CR4)mQ, or (CR, R2)p-C=C-Q;
Ri, R2, R3 and R4 are independently lower-alkyl, optionally substituted with halo;
x is 1-4;
n is 1-5;
m is 1-15;
p is 1-10; and
Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower
alkyl
in a pharmaceutically acceptable carrier.
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