(19)
(11) EP 0 609 588 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
06.09.1995 Bulletin 1995/36

(43) Date of publication A2:
10.08.1994 Bulletin 1994/32

(21) Application number: 93203676.7

(22) Date of filing: 24.12.1993
(51) International Patent Classification (IPC)5A61K 49/04, C07C 22/04, C07C 25/02
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 04.02.1993 US 13605

(71) Applicant: NYCOMED IMAGING AS
N-0485 Oslo (NO)

(72) Inventors:
  • Josef, Kurt A., c/o Sterling Winthrop Inc.
    New York, New York 10016 (US)
  • Bacon, Edward R., c/o Sterling Winthrop Inc.
    New York, New York 10016 (US)
  • Estep, Kimberley G., c/o Sterling Winthrop Inc.
    New York, New York 10016 (US)
  • Illig, Carl, c/o Sterling Winthrop Inc.
    New York, New York 10016 (US)
  • Douty, Brent D., c/o Sterling Winthrop Inc.
    New York, New York 10016 (US)

(74) Representative: Woodman, Derek et al
Frank B. Dehn & Co. European Patent Attorneys Imperial House 15-19 Kingsway
London WC2B 6UZ
London WC2B 6UZ (GB)


(56) References cited: : 
   
       


    (54) Compositions of alkylbenzenes for visualization of the gastrointestinal tract


    (57) Disclosed are contrast agents of the formula


    or pharmaceutically acceptable salts thereof,
    contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein

    R = C1-C25 alkyl, cycloalkyl, unsaturated allyl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxycarbonyl or lower-alkoxycarbonyloxy, (CRi R2)p-(CR3 =CR4)mQ, or (CR1 R2)p-C=C-Q;

    Ri, R2, R3 and R4 are independently H, lower-alkyl, optionally substituted with halo;

    n is 1-5;

    m is 1-5;

    p is 1-10; and

    Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.







    Search report