(19)

(11)

EP 0 611 395 A1

(12)

(43) Date of publication: 24.08.1994 Bulletin 1994/34 (21) Application number: 92923267.0 (22) Date of filing: 04.11.1992

(51) International Patent Classification (IPC):  A01H 5/ 00( . ) C07K 14/ 72( . ) C12N 9/ 12( . ) C12N 15/ 82( . ) C07K 14/ 415( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) (86) International application number: PCT/EP1992/002531 (87) International publication number: WO 1993/009237 (13.05.1993 Gazette 1993/12)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 05.11.1991 US 19910791933 (71) Applicants: SANDOZ LTD. CH-4002 Basel (CH) SANDOZ-ERFINDUNGEN Verwaltungsgesellschaft m.b.H. A-1235 Wien (AT) SANDOZ-PATENT-GMBH D-79539 Lörrach (DE)	(72) Inventors: NICHOLS, Scott, E. Fremont, CA 94539 (US) PAULY, Michael, H. Boise, ID 83702 (US) SINIBALDI, Ralph, M. Fremont, CA 94536 (US) WEEKS, Donald, P. Lincoln, NB 68510 (US) BAKER, Frederick, Charles CH-4123 Allschwil (CH) DUNCAN, Marian, L. Palo Alto, CA 94301 (US)