(19)

(11)

EP 0 614 371 A1

(12)

(43) Date of publication: 14.09.1994 Bulletin 1994/37 (21) Application number: 92925340.0 (22) Date of filing: 13.11.1992

(51) International Patent Classification (IPC):  A61K 39/ 102( . ) A61P 31/ 04( . ) (86) International application number: PCT/US1992/010008 (87) International publication number: WO 1993/009809 (27.05.1993 Gazette 1993/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 15.11.1991 US 19910792490 (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia Pennsylvania 19101 (US)	(72) Inventors: FRANTZ, Joseph, C. Lincoln, NB 68506 (US) KEMMY, Richard, J. Gretna, NB 68028 (US) ROBERTS, David, S. Lincoln, NB 68510 (US) SWEARINGIN, Leroy, A. Lincoln, NB 68510 (US) (74) Representative: Russell, Brian John  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)