(19)

(11)

EP 0 614 491 A1

(12)

(43) Date of publication: 14.09.1994 Bulletin 1994/37 (21) Application number: 93900604.0 (22) Date of filing: 18.11.1992

(51) International Patent Classification (IPC):  C07K 14/ 395( . ) C12N 15/ 81( . ) C12N 15/ 67( . ) (86) International application number: PCT/US1992/010086 (87) International publication number: WO 1993/010250 (27.05.1993 Gazette 1993/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 18.11.1991 US 19910794732 (71) Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY Cambridge, MA 02139 (US)	(72) Inventors: GUARENTE, Leonard Chestnut Hill, MA 02167 (US) BERGER, Shelley Wayne, PA 19087 (US) PINA, Benjamin Somerville, MA 02143 (US) (74) Representative: Greenwood, John David, et al  Graham Watt & Co. Riverhead Sevenoaks Kent TN13 2BN Sevenoaks Kent TN13 2BN (GB)