(19)

(11)

EP 0 615 437 A1

(12)

(43) Date of publication: 21.09.1994 Bulletin 1994/38 (21) Application number: 92923956.0 (22) Date of filing: 01.12.1992

(51) International Patent Classification (IPC):  C07D 311/ 00( . ) A61K 9/ 00( . ) C07D 405/ 00( . ) A61K 31/ 445( . ) (86) International application number: PCT/GB1992/002234 (87) International publication number: WO 1993/010757 (10.06.1993 Gazette 1993/14)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.12.1991 GB 19910025862 19.06.1992 GB 19920013042 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventors: ARCH, Jonathan, Robert, Sanders SmithKline Beecham Epsom Surrey KT18 5XQ (GB) BOWRING, Nicholas, Edward Braintree Essex CM7 4SG (GB) (74) Representative: Rutter, Keith, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)