(19)

(11)

EP 0 616 521 A1

(12)

(43) Date of publication: 28.09.1994 Bulletin 1994/39 (21) Application number: 93901229.0 (22) Date of filing: 10.12.1992

(51) International Patent Classification (IPC):  A61K 8/ 40( . ) A61K 8/ 43( . ) A61K 8/ 55( . ) A61K 8/ 41( . ) A61K 8/ 49( . ) A61Q 11/ 00( . ) (86) International application number: PCT/US1992/010897 (87) International publication number: WO 1993/011741 (24.06.1993 Gazette 1993/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.12.1991 US 19910805598 10.12.1991 US 19910805600 (71) Applicant: THE DOW CHEMICAL COMPANY Midland, Michigan 48640 (US)	(72) Inventors: GARLICH, Joseph R. Lake Jackson, TX 77566 (US) FRANK, R. Keith Lake Jackson, TX 77566 (US) SIMON, Jaime Angleton, TX 77515 (US) KIEFER, Garry E. Lake Jackson, TX 77566 (US) WILSON, David A. Richwood, TX 77531 (US) (74) Representative: Burford, Anthony Frederick  W.H. Beck, Greener & Co. 7 Stone Buildings Lincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)