(19)

(11)

EP 0 618 964 A1

(12)

(43) Date of publication: 12.10.1994 Bulletin 1994/41 (21) Application number: 93901389.0 (22) Date of filing: 14.12.1992

(51) International Patent Classification (IPC):  A61K 38/ 46( . ) C12N 5/ 10( . ) C12N 9/ 72( . ) C12N 15/ 58( . ) C12R 1/ 19( . ) A61P 7/ 02( . ) C12N 9/ 64( . ) C12N 15/ 09( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1992/010677 (87) International publication number: WO 1993/012225 (24.06.1993 Gazette 1993/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.12.1991 US 19910808537 (71) Applicant: GENENTECH, INC. South San Francisco California 94080 (US)	(72) Inventors: HEYNEKER, Herbert, L. Hillsborough, CA 94010 (US) VEHAR, Gordon, A. San Carlos, CA 94070 (US) PAONI, Nicholas, F. Moraga, CA 94556 (US) BENNETT, William, F. San Mateo, CA 94003 (US) (74) Representative: Armitage, Ian Michael, et al  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)