(19)

(11)

EP 0 618 980 A1

(12)

(43) Date of publication: 12.10.1994 Bulletin 1994/41 (21) Application number: 92906329.0 (22) Date of filing: 09.12.1991

(51) International Patent Classification (IPC):  C12Q 1/ 26( . ) C12Q 1/ 60( . ) C12Q 1/ 28( . ) (86) International application number: PCT/US1991/009204 (87) International publication number: WO 1993/012253 (24.06.1993 Gazette 1993/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (71) Applicant: ABBOTT LABORATORIES Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: SALT, Steven, Dale Kirksville, MO 63501 (US) SIEGEL, Neal, Arthur Deerfield, IL 60015 (US) (74) Representative: Modiano, Guido, Dr.-Ing.  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 D-80469 München D-80469 München (DE)