(19)

(11)

EP 0 619 729 A1

(12)

(43) Date of publication: 19.10.1994 Bulletin 1994/42 (21) Application number: 93901989.0 (22) Date of filing: 04.01.1993

(51) International Patent Classification (IPC):  A61K 9/ 08( . ) A61K 9/ 72( . ) A61P 3/ 00( . ) A61K 9/ 00( . ) A61K 31/ 465( . ) A61P 25/ 36( . ) (86) International application number: PCT/CA1993/000003 (87) International publication number: WO 1993/012764 (08.07.1993 Gazette 1993/16)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.01.1992 GB 19920000047 (71) Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA Edmonton, Alberta T6G 2J9 (CA)	(72) Inventor: JONES, Richard, L. Edmonton, Alberta T5H 1L5 (CA) (74) Representative: Bannerman, David Gardner, et al  Withers & Rogers 4 Dyer's Buildings Holborn London, EC1N 2JT London, EC1N 2JT (GB)