(19)

(11)

EP 0 619 744 A1

(12)

(43) Date of publication: 19.10.1994 Bulletin 1994/42 (21) Application number: 93901365.0 (22) Date of filing: 02.12.1992

(51) International Patent Classification (IPC):  A61K 49/ 04( . ) C07D 207/ 263( . ) C07D 207/ 26( . ) C07C 237/ 46( . ) C07D 207/ 273( . ) (86) International application number: PCT/US1992/010629 (87) International publication number: WO 1993/010825 (10.06.1993 Gazette 1993/14)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE (30) Priority: 03.12.1991 US 19910801980 (71) Applicant: MALLINCKRODT MEDICAL, INC. St. Louis, MO 63134 (US)	(72) Inventors: KNELLER, Mills, T. University City, MO 63130 (US) LIN, Youlin Chesterfield, MO 63017 (US) WHEATLEY, James Hazelwood, MO 63042 (US) (74) Representative: Jones, Alan John  CARPMAELS & RANSFORD 43 Bloomsbury Square London, WC1A 2RA London, WC1A 2RA (GB)