(19)

(11)

EP 0 619 840 A1

(12)

(43) Date of publication: 19.10.1994 Bulletin 1994/42 (21) Application number: 93922915.0 (22) Date of filing: 06.10.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 295( . ) C07K 14/ 03( . ) C12N 7/ 00( . ) C12N 15/ 38( . ) C12N 15/ 869( . ) A61K 39/ 245( . ) A61P 31/ 12( . ) C12N 5/ 10( . ) C12N 15/ 00( . ) C12N 15/ 86( . ) (86) International application number: PCT/EP1993/002738 (87) International publication number: WO 1994/008000 (14.04.1994 Gazette 1994/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.10.1992 EP 19920203079 (71) Applicant: Akzo Nobel N.V. NL-6824 BM Arnhem (NL)	(72) Inventor: METTENLEITER, Thomas, Christoph D-7400 Tübingen (DE) (74) Representative: Mestrom, Joannes Jozef Louis, et al  P.O. Box 20 NL-5340 BH Oss NL-5340 BH Oss (NL)