(19)

(11)

EP 0 620 861 A1

(12)

(43) Date of publication: 26.10.1994 Bulletin 1994/43 (21) Application number: 92924356.0 (22) Date of filing: 12.11.1992

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12Q 1/ 68( . ) C07H 21/ 04( . ) (86) International application number: PCT/US1992/009606 (87) International publication number: WO 1993/010264 (27.05.1993 Gazette 1993/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 12.11.1991 US 19910790174 (71) Applicant: ONCOR, INC. Gaithersburg Maryland 20877 (US)	(72) Inventor: GEORGE, Albert, L., Jr. Gaithersburg, MD 20877 (US) (74) Representative: Browne, Robin Forsythe, Dr.  Urquhart-Dykes & Lord Tower House Merrion Way Leeds LS2 8PA West Yorkshire Leeds LS2 8PA West Yorkshire (GB)