(19)

(11)

EP 0 620 939 A1

(12)

(43) Date of publication: 26.10.1994 Bulletin 1994/43 (21) Application number: 92925396.0 (22) Date of filing: 23.11.1992

(51) International Patent Classification (IPC):  C12M 1/ 36( . ) C12N 1/ 00( . ) C12M 3/ 00( . ) G06F 19/ 00( . ) (86) International application number: PCT/US1992/010130 (87) International publication number: WO 1993/011498 (10.06.1993 Gazette 1993/14)

(84) Designated Contracting States: BE CH DE DK ES FR GB IE IT LI NL SE (30) Priority: 25.11.1991 US 19910797311 26.11.1991 US 19910799044 (71) Applicant: CORNELL RESEARCH FOUNDATION, INC. Ithaca, NY 14850 (US)	(72) Inventors: SHULER, Michael, L. Ithaca, NY 14850 (US) BABISH, John, G. Brooktondale, NY 14850 (US) SWEENEY, Lisa, M. White Bear Lake, MN 55110 (US) (74) Representative: Jones, Stephen Anthony, et al  E. N. Lewis & Taylor 144 New Walk Leicester LE1 7JA Leicester LE1 7JA (GB)