(19)

(11)

EP 0 621 778 A1

(12)

(43) Date of publication: 02.11.1994 Bulletin 1994/44 (21) Application number: 93902424.0 (22) Date of filing: 20.01.1993

(51) International Patent Classification (IPC):  C07D 407/ 06( . ) A61K 31/ 42( . ) A61P 31/ 12( . ) C07D 413/ 14( . ) A61K 31/ 35( . ) A61K 31/ 425( . ) A61P 37/ 04( . ) C07D 417/ 14( . ) (86) International application number: PCT/GB1993/000125 (87) International publication number: WO 1993/014752 (05.08.1993 Gazette 1993/19)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 22.01.1992 GB 19920001391 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventors: HANNAN, Peter Charles Thomas Reigate, Surrey RH2 8AT (GB) O'HANLON, Peter John Betchworth, Surrey RH3 7AJ (GB) (74) Representative: Connell, Anthony Christopher  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)