(19)

(11)

EP 0 621 893 A1

(12)

(43) Date of publication: 02.11.1994 Bulletin 1994/44 (21) Application number: 93903066.0 (22) Date of filing: 06.01.1993

(51) International Patent Classification (IPC):  C12P 21/ 00( . ) A61K 39/ 21( . ) C07K 14/ 15( . ) A61K 39/ 00( . ) A61K 39/ 12( . ) A61P 31/ 12( . ) C12N 5/ 06( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1993/000221 (87) International publication number: WO 1993/014190 (22.07.1993 Gazette 1993/18)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.01.1992 US 19920817450 (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia Pennsylvania 19101 (US)	(72) Inventor: HAFFER, Keith Sioux Falls, SD 57103 (US) (74) Representative: Giddings, Peter John, Dr.  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)