(19)

(11)

EP 0 621 894 A1

(12)

(43) Date of publication: 02.11.1994 Bulletin 1994/44 (21) Application number: 93902801.0 (22) Date of filing: 29.12.1992

(51) International Patent Classification (IPC):  A61K 31/ 40( . ) C12N 9/ 10( . ) C12N 9/ 00( . ) (86) International application number: PCT/US1992/011279 (87) International publication number: WO 1993/013197 (08.07.1993 Gazette 1993/16)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL SE (30) Priority: 31.12.1991 US 19910815400 (71) Applicant: PICOWER INSTITUTE FOR MEDICAL RESEARCH Manhasset, NY 10021 (US)	(72) Inventors: SLATER, Andrew, F., G. New York, NY 10021 (US) CERAMI, Anthony New York, NY 11964 (US) (74) Representative: Beresford, Keith Denis Lewis, et al  BERESFORD & Co. 2-5 Warwick Court High Holborn London WC1R 5DJ London WC1R 5DJ (GB)