(19)

(11)

EP 0 623 026 A1

(12)

(43) Date of publication: 09.11.1994 Bulletin 1994/45 (21) Application number: 93903428.0 (22) Date of filing: 14.01.1993

(51) International Patent Classification (IPC):  A61K 39/ 00( . ) A61K 39/ 106( . ) A61P 31/ 04( . ) A61K 39/ 10( . ) A61K 47/ 48( . ) (86) International application number: PCT/US1993/000253 (87) International publication number: WO 1993/013797 (22.07.1993 Gazette 1993/18)

(84) Designated Contracting States: BE DE DK ES FR GB GR IE IT LU NL PT (30) Priority: 16.01.1992 US 19920821453 (71) Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Bethesda, MD 20892-9902 (US)	(72) Inventors: SZU, Shousun, C. Bethesda, MD 20814 (US) ROBBINS, John, B. Chevy Chase, MD 20815 (US) GUPTA, Rajesh, K. Jamaica Plain, MA 02130 (US) (74) Representative: VOSSIUS & PARTNER  P.O. Box 86 07 67 D-81634 München D-81634 München (DE)