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(11)

EP 0 623 147 A1

(12)

(43) Date of publication: 09.11.1994 Bulletin 1994/45 (21) Application number: 93902402.0 (22) Date of filing: 18.01.1993

(51) International Patent Classification (IPC):  A61K 39/ 00( . ) C07K 14/ 74( . ) A61P 31/ 12( . ) (86) International application number: PCT/GB1993/000102 (87) International publication number: WO 1993/014126 (22.07.1993 Gazette 1993/18)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 17.01.1992 GB 19920001023 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)

(72) Inventors: STOTT, Edward James National Inst. for Biological Potters Bar Hertfordshire EN6 3QG (GB) KITCHIN, Peter A. National Inst. for Biological Potters Bar Hertfordshire EN6 3QG (GB) MILLS, Kingston H. G. National Inst. for Biologic. Potters Bar Hertfordshire EN6 3QG (GB) CHAN, Woon, Ling National Institute for Biological Potters Bar Hertfordshire EN6 3QG (GB) PAGE, Mark National Institute for Biological Potters Bar Hertfordshire EN6 3QG (GB) TAFFS, Lesley F. National Institute for Biological Potters Bar Hertfordshire EN6 3QG (GB) (74) Representative: Woods, Geoffrey Corlett  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)