(19)

(11)

EP 0 624 192 A1

(12)

(43) Date of publication: 17.11.1994 Bulletin 1994/46 (21) Application number: 93903639.0 (22) Date of filing: 22.01.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 14/ 82( . ) C07K 19/ 00( . ) C12N 15/ 12( . ) A61K 38/ 00( . ) C07K 14/ 71( . ) C07K 16/ 28( . ) C12N 9/ 12( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1993/000586 (87) International publication number: WO 1993/015201 (05.08.1993 Gazette 1993/19)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.01.1992 US 19920826935 (71) Applicant: NEW ENGLAND DEACONESS HOSPITAL Boston, MA 02215 (US)	(72) Inventors: AVRAHAM, Hava Brighton, MA 02135 (US) GROOPMAN, Jerome Brookline, MA 02146 (US) COWLEY, Sally London W14 8RS (GB) SCADDEN, David Weston, MA 02193 (US) (74) Representative: Holdcroft, James Gerald, Dr., et al  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)