(19)

(11)

EP 0 625 149 A1

(12)

(43) Date of publication: 23.11.1994 Bulletin 1994/47 (21) Application number: 93917412.0 (22) Date of filing: 01.02.1993

(51) International Patent Classification (IPC):  A61K 31/ 443( . ) A61K 31/ 445( . ) A61P 25/ 04( . ) A61P 43/ 00( . ) C07D 409/ 12( . ) A61K 31/ 4433( . ) A61P 25/ 00( . ) A61P 25/ 20( . ) C07D 405/ 12( . ) (86) International application number: PCT/GB1993/000214 (87) International publication number: WO 1993/016072 (19.08.1993 Gazette 1993/20)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.02.1992 GB 19920002510 21.07.1992 GB 19920015499 13.10.1992 GB 19920021446 10.12.1992 GB 19920025788 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventors: KING, Francis David The Pinnacles, Harlow, Essex CM19 5AD (GB) GASTER, Laramie Mary The Pinnacles, Harlow, Essex CM19 5AD (GB) JOINER, Graham Francis The Pinnacles, Harlow, Essex CM 19 5AD (GB) (74) Representative: Tocher, Pauline  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)