(19)

(11)

EP 0 625 205 A1

(12)

(43) Date of publication: 23.11.1994 Bulletin 1994/47 (21) Application number: 93902488.0 (22) Date of filing: 29.01.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 9/ 04( . ) C12P 7/ 42( . ) C12R 1/ 07( . ) C12N 9/ 00( . ) C12N 15/ 00( . ) C12P 41/ 00( . ) C12R 1/ 19( . ) (86) International application number: PCT/GB1993/000204 (87) International publication number: WO 1993/015208 (05.08.1993 Gazette 1993/19)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.01.1992 GB 19920002033 04.03.1992 GB 19920004702 (71) Applicant: Genzyme Limited Haverhill Suffolk CB9 8PU (GB)	(72) Inventors: WILKS, Helen, Margaret Charlottesville, VA 22903 (US) HOLBROOK, Joseph John Timsbury, Bath BA1 (GB) HART, Keith William Orfield, Bristol BS7 0BS (GB) ELHAWRANI, Ayman Bristol BS8 1TD (GB) (74) Representative: Froud, Clive  Elkington and Fife Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)