(19)

(11)

EP 0 626 805 A1

(12)

(43) Date of publication: 07.12.1994 Bulletin 1994/49 (21) Application number: 93904757.0 (22) Date of filing: 28.01.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 37/ 00( . ) C07K 14/ 31( . ) C12P 21/ 02( . ) A61K 39/ 00( . ) C07K 14/ 195( . ) C12N 5/ 10( . ) (86) International application number: PCT/US1993/000839 (87) International publication number: WO 1993/014634 (05.08.1993 Gazette 1993/19)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.01.1992 US 19920827540 (71) Applicant: NATIONAL JEWISH CENTER FOR IMMUNOLOGY AND RESPIRATORY MEDICINE Denver, CO 80206 (US)	(72) Inventors: KAPPLER, John, W. Denver, CO 80207 (US) MARRACK, Philippa Denver, CO 80207 (US) (74) Representative: Lucas, Brian Ronald  Lucas & Co. 135 Westhall Road Warlingham Surrey CR6 9HJ Warlingham Surrey CR6 9HJ (GB)