(19)

(11)

EP 0 626 806 A1

(12)

(43) Date of publication: 07.12.1994 Bulletin 1994/49 (21) Application number: 92905082.0 (22) Date of filing: 17.01.1992

(51) International Patent Classification (IPC):  C12N 1/ 21( . ) C12P 19/ 62( . ) C12N 15/ 52( . ) (86) International application number: PCT/US1992/000427 (87) International publication number: WO 1993/013663 (22.07.1993 Gazette 1993/18)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (71) Applicant: ABBOTT LABORATORIES Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: KATZ, Leonard Waukegan, IL 60085 (US) DONADIO, Stefano Libertyville, IL 60048 (US) MCALPINE, James, B. Libertyville, IL 60048 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 D-80469 München D-80469 München (DE)