(19)

(11)

EP 0 626 852 A1

(12)

(43) Date of publication: 07.12.1994 Bulletin 1994/49 (21) Application number: 93904719.0 (22) Date of filing: 29.01.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 48/ 00( . ) C07H 21/ 04( . ) C12N 15/ 113( . ) A61K 31/ 70( . ) A61P 37/ 00( . ) C12N 5/ 10( . ) (86) International application number: PCT/US1993/000797 (87) International publication number: WO 1993/014769 (05.08.1993 Gazette 1993/19)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 31.01.1992 US 19920830427 14.09.1992 US 19920944868 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94612-3550 (US)	(72) Inventors: WEISS, Tania L. San Rafael, CA 94901 (US) GAROVOY, Marvin R. San Anselmo, CA 94960 (US) HUNT, Anthony San Francisco, CA 94127 (US) HUEY, Bing San Francisco, CA 94122 (US) TAM, Schuman San Francisco, CA 94118 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)