(19)

(11)

EP 0 627 005 A1

(12)

(43) Date of publication: 07.12.1994 Bulletin 1994/49 (21) Application number: 93904216.0 (22) Date of filing: 17.02.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 31/ 12( . ) C12N 1/ 21( . ) C12N 5/ 10( . ) A61K 39/ 00( . ) C12R 1/ 91( . ) A61K 39/ 215( . ) C07K 14/ 165( . ) C12N 5/ 00( . ) C12N 15/ 50( . ) C12R 1/ 19( . ) (86) International application number: PCT/GB1993/000332 (87) International publication number: WO 1993/017109 (02.09.1993 Gazette 1993/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.02.1992 GB 19920003509 (71) Applicant: BRITISH TECHNOLOGY GROUP LIMITED London SE1 6BU (GB)	(72) Inventor: SKINNER, Michael Anthony Wantage, Oxfordshire OX12 9EP (GB) (74) Representative: Percy, Richard Keith  Patents Department British Technology Group Ltd 101 Newington Causeway London SE1 6BU London SE1 6BU (GB)