(19)

(11)

EP 0 628 017 A1

(12)

(43) Date of publication: 14.12.1994 Bulletin 1994/50 (21) Application number: 93900749.0 (22) Date of filing: 24.11.1992

(51) International Patent Classification (IPC):  A61K 6/ 033( . ) A61K 8/ 21( . ) A61K 33/ 06( . ) A61K 33/ 42( . ) C01B 25/ 16( . ) C01B 25/ 455( . ) A61K 8/ 19( . ) A61K 8/ 24( . ) A61K 33/ 24( . ) A61Q 11/ 00( . ) C01B 25/ 26( . ) C01F 11/ 22( . ) (86) International application number: PCT/US1992/010307 (87) International publication number: WO 1994/004460 (03.03.1994 Gazette 1994/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.08.1992 US 19920936068 (71) Applicant: AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION Chicago, IL 60611-2678 (US)	(72) Inventor: TUNG, Ming, S. Gaithesburg, MD 20878 (US) (74) Representative: Brooks, Nigel Samuel  Hill Hampton East Meon Petersfield Hampshire GU32 1QN Petersfield Hampshire GU32 1QN (GB)