(19)

(11)

EP 0 628 079 A1

(12)

(43) Date of publication: 14.12.1994 Bulletin 1994/50 (21) Application number: 93904270.0 (22) Date of filing: 26.02.1993

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 39/ 395( . ) C07K 7/ 06( . ) C07K 16/ 00( . ) C12N 15/ 51( . ) C12P 21/ 08( . ) C12Q 1/ 70( . ) A61K 39/ 00( . ) A61K 39/ 29( . ) A61P 31/ 12( . ) C07K 14/ 18( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) G01N 33/ 576( . ) (86) International application number: PCT/GB1993/000410 (87) International publication number: WO 1993/017111 (02.09.1993 Gazette 1993/21)

(84) Designated Contracting States: AT BE CH DE ES FR GB IE IT LI NL SE (30) Priority: 28.02.1992 GB 19920004274 (71) Applicant: THE WELLCOME FOUNDATION LIMITED London NW1 2BP (GB)	(72) Inventor: PIKE, Ian Bromley, Kent. BR2 9RX (GB) (74) Representative: Marchant, James Ian, et al  Elkington and Fife Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)