(19)
(11) EP 0 629 184 A1

(12)

(43) Date of publication:
21.12.1994 Bulletin 1994/51

(21) Application number: 93905607.0

(22) Date of filing: 03.03.1993
(51) International Patent Classification (IPC): 
C12N 9/ 99( . )
A61K 31/ 215( . )
A61K 31/ 366( . )
A61P 3/ 06( . )
C07C 69/ 30( . )
C07D 309/ 30( . )
C12P 7/ 42( . )
C12P 17/ 12( . )
 A61K 31/ 19( . )
A61K 31/ 365( . )
A61P 3/ 00( . )
C07C 59/ 54( . )
C07C 69/ 732( . )
C12N 1/ 20( . )
C12P 17/ 06( . )
C12R 1/ 01( . )
(86) International application number:
PCT/JP1993/000266
(87) International publication number:
WO 1993/017991 (16.09.1993 Gazette 1993/22)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

(30) Priority: 04.03.1992 GB 19920004810
21.08.1992 GB 19920017822

(71) Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
Osaka-shi Osaka 541 (JP)

(72) Inventors:
  • GOTO, Toshio
    Tsukuba-shi, Ibaraki 305 (JP)
  • SHIBATA, Toshihiro
    Ryugasaki-shi, Ibaraki 301 (JP)
  • OKUHARA, Masakuni
    Tsukuba-shi, Ibaraki 305 (JP)
  • SAKAMOTO, Kazutoshi
    Tsuchiura-shi, Ibaraki 300 (JP)
  • HATANAKA, Hiroshi
    Kitasouma-gun, Ibaraki 305 (JP)
  • TAKASE, Shigehiro
    Ishioka-shi, Ibaraki 315 (JP)
  • SATO, Tomoko
    Tsukuba-shi, Ibaraki 305 (JP)

(74) Representative: Türk, Dietmar, Dr. rer. nat., et al 
Türk, Gille, Hrabal, Leifert Patentanwälte Brucknerstrasse 20
D-40593 Düsseldorf
D-40593 Düsseldorf (DE)

   


(54) TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS