(19)

(11)

EP 0 630 251 A1

(12)

(43) Date of publication: 28.12.1994 Bulletin 1994/52 (21) Application number: 93907684.0 (22) Date of filing: 18.03.1993

(51) International Patent Classification (IPC):  A61K 45/ 06( . ) (86) International application number: PCT/CA1993/000109 (87) International publication number: WO 1993/018775 (30.09.1993 Gazette 1993/24)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 19.03.1992 US 19920854406 (71) Applicant: THE UNIVERSITY OF BRITISH COLUMBIA Vancouver, British Columbia, V6T 1W5 (CA)	(72) Inventors: BURTON, Albert F. Comox, British Columbia V9N 4Z9 (CA) FREEMAN, Hugh J. Vancouver, British Columbia (CA) MCGEER, Patrick L. Vancouver, British Columbia (CA) (74) Representative: Nash, David Allan, et al  Haseltine Lake & Co. Hazlitt House 28 Southampton Buildings Chancery Lane London WC2A 1AT London WC2A 1AT (GB)