(19)

(11)

EP 0 631 584 A1

(12)

(43) Date of publication: 04.01.1995 Bulletin 1995/01 (21) Application number: 92907799.0 (22) Date of filing: 28.02.1992

(51) International Patent Classification (IPC):  C07K 14/ 47( . ) G01N 33/ 50( . ) A61K 38/ 00( . ) C12Q 1/ 68( . ) G01N 33/ 574( . ) (86) International application number: PCT/US1992/001624 (87) International publication number: WO 1992/015602 (17.09.1992 Gazette 1992/24)

(84) Designated Contracting States: CH DE FR GB IT LI SE (30) Priority: 28.02.1991 US 19910662216 (71) Applicant: DANA FARBER CANCER INSTITUTE Boston Massachusetts 02115 (US)	(72) Inventor: SAGER, Ruth Brookline, MA 02146 (US) (74) Representative: Allard, Susan Joyce, et al  BOULT, WADE & TENNANT 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)