(19)

(11)

EP 0 632 832 A1

(12)

(43) Date of publication: 11.01.1995 Bulletin 1995/02 (21) Application number: 94915331.0 (22) Date of filing: 21.01.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 1/ 21( . ) C12N 9/ 12( . ) C12P 21/ 08( . ) C12R 1/ 19( . ) C07K 16/ 40( . ) C12N 5/ 10( . ) C12N 15/ 54( . ) A61K 38/ 00( . ) C12R 1/ 865( . ) (86) International application number: PCT/US1994/000795 (87) International publication number: WO 1994/017189 (04.08.1994 Gazette 1994/18)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.01.1993 US 19930008001 (71) Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES La Jolla California 92037 (US)	(72) Inventor: HOEKSTRA, Merl, F. Shohomish, WA 98290 (US) (74) Representative: Gowshall, Jonathan Vallance  FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 D-80801 München D-80801 München (DE)